HJB

杭州奕安济世, HJB, CDMO, biologics,

HJB

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SERVICES
  • Candidate selection based on molecule thermo stability and manufacturability;
    Early identification of potential critical quality attributes.

  • Recombinant antibody / FC-fusion protein research grade material CHO cell based production;
    Grams of antibody in 6 weeks from DNA to QC'd material.

  • Establish high titer bulk pools from DNA in 2 weeks for CMC development;
    Typical titer > 1.5 g/L at pool stage; > 3.5 g/L for single clones

  • In-house developed chemically defined media, robust cell line expression system and extensive technical expertise makes continuous bioprocessing applicable and affordable to any protein biologics.

  • Robust and high-quality Upstream process for mAb production;
    Industry-standard Downstream process to reduce product and process related impurities.

  • Physical and chemical properties, purity, impurity, protein structure, affinity and other services,
    covering almost full quality attributes in biopharmaceuticals

  • A complete panel of biophysical and biochemical testing available in-house to support product development.
    We also offer individual testing services.

  • 50L~2000L scale cell culture and drug substance;
    BOSCH Isolated Vial Drug Product Filling line will be ready in 2020

  • Stability and compatibility studies are performed with state-of-art facilities
    under long term, accelerated, stressed etc. conditions.

  • Customized services on your needs;
    Complete the manufacturing of your Master Cell Bank / Working Cell Bank efficiently.

  • Comprehensive and professional regulatory strategy support including
    pre-IND meeting preparation, IND filing package and other consultation.

ABOUT US

HJB was founded by an experienced team spanning the fields of protein, process and manufacturing sciences. We aim to break the scientific and technical hurdles inhibiting patients’ access to life changing biologics therapeutics.

ADVANTAGE
Holistic and integrated approach from DNA to DP for rapid development and efficient manufacturing.
Developability for Candidate Selection

Nominating a development candidate with manufacturing liability can have big consequences. Yet a thorough candidate selection campaign is still too demanding using conventional approach for both time and cost. HJB offers a proprietary solution to allow rapid, flexible and reliable assessment in parallel with cell line development.

Nominating a development candidate with manufacturing liability can have big consequences. Yet a thorough candidate selection campaign is still too demanding using conventional approach for both time and cost. HJB offers a proprietary solution to allow rapid, flexible and reliable assessment in parallel with cell line development.

Platform Process

Quickly getting to clinical proof-of-concept is your primary goal. At HJB we believe innovators should not be burdened with excess amount of process development work early on. That’s why our team pre-optimized the entire platform for typical antibodies to help you reach the first-in-human milestone fast without compromising quality.

Quickly getting to clinical proof-of-concept is your primary goal. At HJB we believe innovators should not be burdened with excess amount of process development work early on. That’s why our team pre-optimized the entire platform for typical antibodies to help you reach the first-in-human milestone fast without compromising quality.

Advanced Manufacturing

It is critical for company to secure low COGS supply, so drugs can be affordable to patients and their scientists can continue to innovate. HJB combines world-leading modular facilities, high productivity cell lines, internally developed media and efficient integrated continuous process to help you gain the edge on COGS control.

It is critical for company to secure low COGS supply, so drugs can be affordable to patients and their scientists can continue to innovate. HJB combines world-leading modular facilities, high productivity cell lines, internally developed media and efficient integrated continuous process to help you gain the edge on COGS control.

In just 1.5 years after facility inauguration and validation,
we have achieved:

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Projects Contracted

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Clients Served

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GMP Batches Delivered

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Cell Lines Developed

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